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Eukaryon

Class Year

2006

Keywords

Parkinson’s Disease

Abstract

Parkinson’s Disease is a neurodegenerative disease that is pathologically characterized by abnormal a-synuclein protein aggregation, dopamine depletion in nigrostriatal neurons, and the subsequent death of these neurons. Oxidative stress has been widely implicated as a cause for neurodegenerative diseases, especially Parkinson’s Disease (PD). The mechanisms by which oxidative stress occurs in PD neurons and causes cell death remain obscure. Recent research has revealed several mechanisms by which a-synuclein and oxidative stress may induce cell death in PD, providing potential targets for therapies. The roles of a-synuclein, PD-inducing drugs, and DJ-1 as well as their involvement in oxidative stress production and apoptosis are reviewed.

Disclaimer

Eukaryon is published by students at Lake Forest College, who are solely responsible for its content. The views expressed in Eukaryon do not necessarily reflect those of the College. Articles published within Eukaryon should not be cited in bibliographies. Material contained herein should be treated as personal communication and should be cited as such only with the consent of the author.

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