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Presentation Title

Repeated Drug Exposure Disrupts Rat Hippocampal Neurons During Adolescent Brain Development

Student Presenter(s) and Advisor

Kimberly Diah '13Follow

Location

Meyer Auditorium

Abstract

Exposure to addictive and non-addictive drugs during adolescence increases susceptibility to neuropsychiatric disorders. GABA interneurons mediate maturation of the prefrontal cortex (PFC) and hippocampus during adolescence. Recent findings indicate that these drugs disrupt GABA interneurons in the maturing PFC, but effects on hippocampus are unknown. For my thesis, I investigated three such drugs for effects on hippocampal GABA interneurons in adolescent rats. I found developmental disregulation of GABA interneurons to cocaine and a glutamate agonist, but not to a marijuana-mimic. This research was performed in Dr. Kuei Yuan Tseng's Laboratory at Rosalind Franklin University of Medicine and Science.

Presentation Type

Individual Presentation

Start Date

4-9-2013 10:00 AM

End Date

4-9-2013 10:20 AM

Panel

Panel: Frontiers of the Human Body

Panel Moderator

Jennifer Jeziorski

Field of Study for Presentation

Neuroscience

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Apr 9th, 10:00 AM Apr 9th, 10:20 AM

Repeated Drug Exposure Disrupts Rat Hippocampal Neurons During Adolescent Brain Development

Meyer Auditorium

Exposure to addictive and non-addictive drugs during adolescence increases susceptibility to neuropsychiatric disorders. GABA interneurons mediate maturation of the prefrontal cortex (PFC) and hippocampus during adolescence. Recent findings indicate that these drugs disrupt GABA interneurons in the maturing PFC, but effects on hippocampus are unknown. For my thesis, I investigated three such drugs for effects on hippocampal GABA interneurons in adolescent rats. I found developmental disregulation of GABA interneurons to cocaine and a glutamate agonist, but not to a marijuana-mimic. This research was performed in Dr. Kuei Yuan Tseng's Laboratory at Rosalind Franklin University of Medicine and Science.