Complete Schedule of Events

Location

Meyer Auditorium

Abstract

Parkinson’s disease (PD) is linked to the compromised degradation of the protein α-synuclein. Therefore, increasing α-synuclein degradation is of therapeutic interest. Endocytosis is hypothesized to be a route to α-synuclein degradation at the lysosome. Recently, our lab found that several endocytic genes regulate PD-related α-synuclein properties. Most importantly, vps28 deletion alters α-synuclein localization and increases its accumulation and toxicity in yeast cells. I extended this work and observed that increasing the concentration of α-synuclein in vps28-lacking yeast further enhances α-synuclein accumulation and toxicit. This work illustrates the growing relevance of endocytosis in PD pathology.

Presentation Type

Individual Presentation

Start Date

4-9-2013 10:40 AM

End Date

4-9-2013 11:00 AM

Panel

Panel: Frontiers of the Human Body

Panel Moderator

Jennifer Jeziorski

Field of Study for Presentation

Neuroscience

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Apr 9th, 10:40 AM Apr 9th, 11:00 AM

Understanding Parkinson’s Disease Pathology in Yeast: A Role for Endocytosis

Meyer Auditorium

Parkinson’s disease (PD) is linked to the compromised degradation of the protein α-synuclein. Therefore, increasing α-synuclein degradation is of therapeutic interest. Endocytosis is hypothesized to be a route to α-synuclein degradation at the lysosome. Recently, our lab found that several endocytic genes regulate PD-related α-synuclein properties. Most importantly, vps28 deletion alters α-synuclein localization and increases its accumulation and toxicity in yeast cells. I extended this work and observed that increasing the concentration of α-synuclein in vps28-lacking yeast further enhances α-synuclein accumulation and toxicit. This work illustrates the growing relevance of endocytosis in PD pathology.