Complete Schedule of Events

Presentation Title

Localization of PABPC1 in HeLa Cells

Student Presenter(s) and Advisor

Emily Hampden-Smith '13Follow

Location

Calvin Durand

Abstract

Oculopharyngeal muscular dystrophy (OPMD) is a late onset disease characterized by eyelid drooping and difficulty swallowing, which decreases quality of life. OPMD is linked to a mutation in the gene for an RNA-binding protein called PABPN1, which is localized in the nucleus. A related protein, PABPC1, is normally localized in the cytoplasm rather than the nucleus. Recent studies have shown that PABPC1 actively shuttles between the cytoplasm and the nucleus, but its function is unknown. I looked at fluorescent images of PABPC1 in HeLa cells to determine the location and number of cells that expressed PABPC1 in the nucleus.

Presentation Type

Poster

Start Date

4-9-2013 1:00 PM

End Date

4-9-2013 2:30 PM

Panel

Posters

Field of Study for Presentation

Biology

No downloadable materials are available for this event.

Share

Import Event to Google Calendar

COinS
 
Apr 9th, 1:00 PM Apr 9th, 2:30 PM

Localization of PABPC1 in HeLa Cells

Calvin Durand

Oculopharyngeal muscular dystrophy (OPMD) is a late onset disease characterized by eyelid drooping and difficulty swallowing, which decreases quality of life. OPMD is linked to a mutation in the gene for an RNA-binding protein called PABPN1, which is localized in the nucleus. A related protein, PABPC1, is normally localized in the cytoplasm rather than the nucleus. Recent studies have shown that PABPC1 actively shuttles between the cytoplasm and the nucleus, but its function is unknown. I looked at fluorescent images of PABPC1 in HeLa cells to determine the location and number of cells that expressed PABPC1 in the nucleus.