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Presentation Title

Co-regulation of pre-mRNA alternative splicing and microRNA biogenesis

Student Presenter(s) and Advisor

Ashley Reich '13Follow

Location

Meyer Auditorium

Abstract

This study focuses on two ubiquitous post-transcriptional gene expression regulatory mechanisms: host gene pre-messenger RNA (pre-mRNA) alternative splicing and microRNA biogenesis. We hypothesize that the two processes are co-regulated, and that microRNA biogenesis will impact alternative splicing patterns of mRNA transcripts. We altered both the microRNA biogenesis and alternative splicing pathways and found that factors involved in microRNA biogenesis, with no previously known splicing function, can modify alternative splicing. We conclude the two processes are co-regulated, and that the microprocessor may have a role in alternative splicing. This research was performed in Dr. Michelle Hasting's Laboratory at Rosalind Franklin Medical School.

Presentation Type

Individual Presentation

Start Date

4-9-2013 1:20 PM

End Date

4-9-2013 1:40 PM

Panel

Panel: The Gene Genie: Scientific Discoveries about the Cell

Panel Moderator

David Levinson

Field of Study for Presentation

Biology

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Apr 9th, 1:20 PM Apr 9th, 1:40 PM

Co-regulation of pre-mRNA alternative splicing and microRNA biogenesis

Meyer Auditorium

This study focuses on two ubiquitous post-transcriptional gene expression regulatory mechanisms: host gene pre-messenger RNA (pre-mRNA) alternative splicing and microRNA biogenesis. We hypothesize that the two processes are co-regulated, and that microRNA biogenesis will impact alternative splicing patterns of mRNA transcripts. We altered both the microRNA biogenesis and alternative splicing pathways and found that factors involved in microRNA biogenesis, with no previously known splicing function, can modify alternative splicing. We conclude the two processes are co-regulated, and that the microprocessor may have a role in alternative splicing. This research was performed in Dr. Michelle Hasting's Laboratory at Rosalind Franklin Medical School.