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Presentation Title

Pot1: Babysitting the End of the Telomere

Student Presenter(s) and Advisor

Tyler Hauer '13Follow

Location

Meyer Auditorium

Abstract

Aspergilli possess short and tightly regulated telomeres, the protective caps at the ends of chromosomes. A protein (Pot1/NIMU) has been identified in Aspergillus nidulans that may bind to the single-stranded overhang of the telomeres. No studies have been done regarding the importance of Pot1/NIMU to telomere maintenance in Aspergillus. I work with a temperature sensitive mutant of A. nidulans, which does not possess functional Pot1/NIMU at elevated temperatures. This mutant displays extremely variable telomere length, evident when compared to the tightly regulated telomeres of the wild type strain. These findings identify Pot1/NIMU as a key player in telomere length regulation.

Presentation Type

Individual Presentation

Start Date

4-9-2013 1:40 PM

End Date

4-9-2013 2:00 PM

Panel

Panel: The Gene Genie: Scientific Discoveries about the Cell

Panel Moderator

David Levinson

Field of Study for Presentation

Biology

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Apr 9th, 1:40 PM Apr 9th, 2:00 PM

Pot1: Babysitting the End of the Telomere

Meyer Auditorium

Aspergilli possess short and tightly regulated telomeres, the protective caps at the ends of chromosomes. A protein (Pot1/NIMU) has been identified in Aspergillus nidulans that may bind to the single-stranded overhang of the telomeres. No studies have been done regarding the importance of Pot1/NIMU to telomere maintenance in Aspergillus. I work with a temperature sensitive mutant of A. nidulans, which does not possess functional Pot1/NIMU at elevated temperatures. This mutant displays extremely variable telomere length, evident when compared to the tightly regulated telomeres of the wild type strain. These findings identify Pot1/NIMU as a key player in telomere length regulation.