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Presentation Title

Knocking out the telomerase RNA sequence in a filamentous fungus

Student Presenter(s) and Advisor

Amanda Allred, Lake Forest CollegeFollow

Location

Library 203

Abstract

Telomeres are protective complexes at chromosome ends. Telomere length is maintained by telomerase, which comprises a telomerase reverse transcriptase (TERT) and telomerase RNA (TER). Little is known about these components in filamentous fungi. Aspergillus nidulans possesses exceptionally short, tightly regulated telomeres. Our lab identified the TER sequence of A. nidulans. We hypothesize the deletion of this sequence will lead to telomere deregulation and cell death. My thesis involves knocking out TER to see if this deletion results in telomere loss. This study will confirm the identification of TER in A. nidulans, and ultimately determine how these short telomeres are maintained.

Presentation Type

Individual Presentation

Start Date

4-8-2014 10:40 AM

End Date

4-8-2014 12:00 PM

Panel

Panel: Topics in Biology: Ecological, Clinical and Molecular Analyses

Field of Study for Presentation

Biology

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Apr 8th, 10:40 AM Apr 8th, 12:00 PM

Knocking out the telomerase RNA sequence in a filamentous fungus

Library 203

Telomeres are protective complexes at chromosome ends. Telomere length is maintained by telomerase, which comprises a telomerase reverse transcriptase (TERT) and telomerase RNA (TER). Little is known about these components in filamentous fungi. Aspergillus nidulans possesses exceptionally short, tightly regulated telomeres. Our lab identified the TER sequence of A. nidulans. We hypothesize the deletion of this sequence will lead to telomere deregulation and cell death. My thesis involves knocking out TER to see if this deletion results in telomere loss. This study will confirm the identification of TER in A. nidulans, and ultimately determine how these short telomeres are maintained.