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Presentation Title

Evidence for the Role of Endocytosis in Parkinson's Disease: Insights from a Budding Yeast Model

Student Presenter(s) and Advisor

Maiwase Tembo '15, Lake Forest CollegeFollow

Location

Durand Art Institute, 2nd Floor Balcony

Abstract

Parkinson's disease (PD) is linked to impaired degradation and accumulation of the misfolded protein, alpha-synuclein. Therefore, accelerating the degradation of alpha-synuclein is of therapeutic interest. Our lab has tested the hypothesis that α-synuclein uses endocytosis as a route to the lysosome for its degradation. We have found evidence that several endocytosis genes regulate α–synuclein's PD related properties. Most importantly, the absence of vps28 increases α-synuclein aggregation and cellular accumulation, and confers toxicity in a yeast PD model. I, specifically, found that increasing the concentration of α-synuclein in yeast that lack vps28 further enhances each of these pathological characteristics.

Presentation Type

Poster

Start Date

4-8-2014 2:40 PM

End Date

4-8-2014 4:00 PM

Panel

Posters: The Ken Weik Poster Session

Field of Study for Presentation

Neuroscience

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Apr 8th, 2:40 PM Apr 8th, 4:00 PM

Evidence for the Role of Endocytosis in Parkinson's Disease: Insights from a Budding Yeast Model

Durand Art Institute, 2nd Floor Balcony

Parkinson's disease (PD) is linked to impaired degradation and accumulation of the misfolded protein, alpha-synuclein. Therefore, accelerating the degradation of alpha-synuclein is of therapeutic interest. Our lab has tested the hypothesis that α-synuclein uses endocytosis as a route to the lysosome for its degradation. We have found evidence that several endocytosis genes regulate α–synuclein's PD related properties. Most importantly, the absence of vps28 increases α-synuclein aggregation and cellular accumulation, and confers toxicity in a yeast PD model. I, specifically, found that increasing the concentration of α-synuclein in yeast that lack vps28 further enhances each of these pathological characteristics.