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Presentation Title

Evaluation of alpha-synuclein splice variants in yeast to better understand Parkinson’s Disease

Location

Durand Art Institute, 2nd Floor Balcony

Abstract

Parkinson's disease (PD) is a hypokinetic disorder characterized by midbrain neuron loss that results from misfolded α-synuclein. Till recently, full-length α-synuclein was considered the diseased form. Recently, smaller variants of α-synuclein formed through alternative splicing (α-syn 126, α-syn 112, and α-syn 98) have been found in patients, but their significance in unclear. We hypothesized that these splice variants contribute to PD because they lack regions important for function. We will explain how we created these variants this past year to study them in a yeast model. We next plan to evaluate whether they are more toxic than the full-length form,

Presentation Type

Poster

Start Date

4-8-2014 2:40 PM

End Date

4-8-2014 4:00 PM

Panel

Posters: The Ken Weik Poster Session

Field of Study for Presentation

Neuroscience

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Apr 8th, 2:40 PM Apr 8th, 4:00 PM

Evaluation of alpha-synuclein splice variants in yeast to better understand Parkinson’s Disease

Durand Art Institute, 2nd Floor Balcony

Parkinson's disease (PD) is a hypokinetic disorder characterized by midbrain neuron loss that results from misfolded α-synuclein. Till recently, full-length α-synuclein was considered the diseased form. Recently, smaller variants of α-synuclein formed through alternative splicing (α-syn 126, α-syn 112, and α-syn 98) have been found in patients, but their significance in unclear. We hypothesized that these splice variants contribute to PD because they lack regions important for function. We will explain how we created these variants this past year to study them in a yeast model. We next plan to evaluate whether they are more toxic than the full-length form,