Class Year

2013

Date

4-16-2013

Document Type

Thesis

Distinguished Thesis

yes

Degree Name

Bachelor of Arts (BA)

Department or Program

Biology

First Advisor

Lynn C. Westley

Second Advisor

Anne E. Houde

Third Advisor

Robert B. Glassman

Fourth Advisor

Rachel Neff Greenley, Rosalind Frankin University of Medicine and Science

Abstract

Objective: To summarize rates of supplement adherence in youth with inflammatory bowel disease (IBD) and to identify predictors and outcomes of supplement adherence.

Methods: 49 adolescents (ages 11-18) participated. Youth completed six monthly assessments of adherence and supplement knowledge. Youth and parents completed questionnaires. Medical record reviews provided medical and laboratory data.

Results: Mean supplement adherence rates ranged from 32% to 44%. Predictors of supplement adherence included higher knowledge (for multivitamin, iron, and calcium adherence) higher family involvement (for iron and calcium adherence), and greater inflammation (via a hematological index) for multivitamin adherence. Few relationships between supplement adherence and inflammation, growth, or nutritional outcomes were found.

Conclusion: Supplement adherence is problematic in pediatric IBD, and predictors of adherence tended to be psychosocial rather than biological variables. Future research with larger sample sizes and assessments of supplement adherence that do not rely solely on patient self-report are important next steps.

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