Class Year

2016

Date

4-15-2016

Document Type

Thesis

Distinguished Thesis

Yes

Degree Name

Bachelor of Arts (BA)

Department or Program

Neuroscience

First Advisor

Anne Houde

Second Advisor

Todd Beer

Third Advisor

Naomi Wentworth

Fourth Advisor

Jeremy Amiel Rosenkranz, Rosalind Franklin University

Abstract

Developing a new hypothesis for the pathophysiological mechanism of depression is necessary to further understanding of the disease. The purpose of this study was to test the hypothesis that depression is contagious. I predicted that naïve rats cross-housed with rats subjected to social defeat would develop depressive-like behaviors similar to their socially defeated cage mates. In addition, ΔFosB expression between the two groups should be parallel in brain areas implicated in depression, specifically the infralimbic prefrontal cortex. Trends were observed that supported the hypothesis presented. It is imperative to explore new avenues of research and strive to develop more effective and scientifically informed treatment options for those who suffer from depression.


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