migraine, Cav2.1 channel
Migraine headache is a common, chronic, debilitating pain that affects roughly 6-8% of men and 15-18% of women in the U.S. and Europe (WHO, 2004). In the U.S., the annual cost of migraine treatment ranges from 13-17 billion dollars (Goldberg, 2005; Blumenfeld, 2005). Often it causes deficits in cognition, function, and sleep. Until recently, no research had defined the molecular basis for such a widespread illness. However, a remarkable study conducted by Maagdenberg and colleagues (2004) suggested that mutations in a gene encoding neuronal calcium channels were the molecular basis for migraine.
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