2016 - 19th Annual Steven Galovich Memorial Student Symposium
Presentation Title
Effects of Repeated Concussive Traumatic Brain Injury at Acute and Chronic Time Points
Location
Library First Floor
Abstract
Traumatic brain injuries (TBI), particularly concussions from sports or combat, are increasingly common and thought to increase the likelihood of neurodegenerative diseases, such as chronic traumatic encephalopathy. The sequence of degenerative/regenerative responses underlying these disorders has been unclear and was the focus of this study. We utilized a controlled cortical impactor to deliver injury to rats. Our results indicate that there was neuronal cell loss in specific regions of the hippocampus. Additionally, there was a decrease in hippocampal and corpus callosal volume and an increase in ventricular size. Future studies will examine the use of rabies viral vectors to enhance regeneration.
Presentation Type
Individual Presentation
Start Date
4-5-2016 2:30 PM
End Date
4-5-2016 3:45 PM
Panel
Trauma Studies of the Brain and Body
Panel Moderator
Siobhan Moroney
Field of Study for Presentation
Biology, Neuroscience
Effects of Repeated Concussive Traumatic Brain Injury at Acute and Chronic Time Points
Library First Floor
Traumatic brain injuries (TBI), particularly concussions from sports or combat, are increasingly common and thought to increase the likelihood of neurodegenerative diseases, such as chronic traumatic encephalopathy. The sequence of degenerative/regenerative responses underlying these disorders has been unclear and was the focus of this study. We utilized a controlled cortical impactor to deliver injury to rats. Our results indicate that there was neuronal cell loss in specific regions of the hippocampus. Additionally, there was a decrease in hippocampal and corpus callosal volume and an increase in ventricular size. Future studies will examine the use of rabies viral vectors to enhance regeneration.