Presentation Title

Alone, anxious, and unable to forget: Modeling social isolation in rats

Student Presenter(s) and Advisor

Michael Janecek, Lake Forest CollegeFollow

Location

Lilliard Science Center A 044

Abstract

Social isolation, an environmental stressor, induces anxiety and prolongs recovery from psychological trauma in humans. In the present study, we utilized a fear-potentiated startle paradigm, a valid measure of anxiety observable in rodents and humans, to model continuous isolation in rats. We found that while short-term isolation did not affect fear-learning, continuous isolation prolonged cued fear extinction. Surprisingly, isolation did not affect threat discrimination ability. These findings highlight the critical role of social environment in the modulation of fear memory, opening new avenues of investigation.

Presentation Type

Individual Presentation

Start Date

4-10-2018 10:30 AM

End Date

4-10-2018 11:45 AM

Panel

Scientific Studies

Panel Moderator

Lynette Foss

Field of Study for Presentation

Neuroscience

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Apr 10th, 10:30 AM Apr 10th, 11:45 AM

Alone, anxious, and unable to forget: Modeling social isolation in rats

Lilliard Science Center A 044

Social isolation, an environmental stressor, induces anxiety and prolongs recovery from psychological trauma in humans. In the present study, we utilized a fear-potentiated startle paradigm, a valid measure of anxiety observable in rodents and humans, to model continuous isolation in rats. We found that while short-term isolation did not affect fear-learning, continuous isolation prolonged cued fear extinction. Surprisingly, isolation did not affect threat discrimination ability. These findings highlight the critical role of social environment in the modulation of fear memory, opening new avenues of investigation.