2019 - 22nd Annual Steven Galovich Memorial Student Symposium

Presentation Title

Establishing a Biocompatible Organic Reaction to Metabolize Diclofenac in Water

Student Presenter(s) and Advisor

Rhyan B. Shanker, Lake Forest CollegeFollow

Department or Major

Chemistry

Location

Lillard Lobby

Abstract

The biocompatible metabolism of drugs has been explored to remedy the trace amounts of pharmaceuticals in the water supply. Pharmaceuticals are designed to not be metabolized by the microbes in our gut, and, consequently, the microbes in waste water treatment facilities (WWTFs) cannot decompose these compounds. The pharmaceutical under study is the NSAID diclofenac, which has devastating effects on vultures and aquatic organisms. Research focuses on establishing a reaction that will convert diclofenac into a metabolizable molecule under conditions compatible with WWTFs. Results are being actively developed. A palladium-catalyzed dehalogenation reaction has been found and yields the desired product.

Presentation Type

Poster

Start Date

4-9-2019 1:00 PM

End Date

4-9-2019 2:15 PM

Panel

Poster Session

Field of Study for Presentation

Chemistry

No downloadable materials are available for this event.

Share

COinS
 
Apr 9th, 1:00 PM Apr 9th, 2:15 PM

Establishing a Biocompatible Organic Reaction to Metabolize Diclofenac in Water

Lillard Lobby

The biocompatible metabolism of drugs has been explored to remedy the trace amounts of pharmaceuticals in the water supply. Pharmaceuticals are designed to not be metabolized by the microbes in our gut, and, consequently, the microbes in waste water treatment facilities (WWTFs) cannot decompose these compounds. The pharmaceutical under study is the NSAID diclofenac, which has devastating effects on vultures and aquatic organisms. Research focuses on establishing a reaction that will convert diclofenac into a metabolizable molecule under conditions compatible with WWTFs. Results are being actively developed. A palladium-catalyzed dehalogenation reaction has been found and yields the desired product.