2019 - 22nd Annual Steven Galovich Memorial Student Symposium

Presentation Title

Investigation of the Neuroinflammatory Response in Hippocampal Subfields After a Single Mild Traumatic Brain Injury (mTBI) in Rats

Department or Major

1. Neuroscience & Psychology

2. Neuroscience

3. Neuroscience

4. Neuroscience

Location

Lillard 044

Abstract

Mild forms of traumatic brain injury (mTBI), such as concussions from falls or sports, are often associated with memory deficits. We recently described a clinically relevant closed-head model for mTBI in rats, and are using this model to evaluate mechanisms of neuroinflammation and explore possible therapeutic strategies. Rat brains were immunostained to detect mature neurons, astrocytes, and microglia. These sections were imaged and analyzed using Stereo-Investigator software to evaluate neuronal loss and inflammation in hippocampal subfields. Establishing these effects after mTBI would provide a model for investigating regenerative approaches to replacing neurons through reprogramming in the hippocampal CA subfields.

Presentation Type

Individual Presentation

Start Date

4-9-2019 10:30 AM

End Date

4-9-2019 11:45 AM

Panel

New Frontiers in Medical Research

Panel Moderator

Jean-Marie Maddux

Field of Study for Presentation

Neuroscience, Psychology

No downloadable materials are available for this event.

Share

COinS
 
Apr 9th, 10:30 AM Apr 9th, 11:45 AM

Investigation of the Neuroinflammatory Response in Hippocampal Subfields After a Single Mild Traumatic Brain Injury (mTBI) in Rats

Lillard 044

Mild forms of traumatic brain injury (mTBI), such as concussions from falls or sports, are often associated with memory deficits. We recently described a clinically relevant closed-head model for mTBI in rats, and are using this model to evaluate mechanisms of neuroinflammation and explore possible therapeutic strategies. Rat brains were immunostained to detect mature neurons, astrocytes, and microglia. These sections were imaged and analyzed using Stereo-Investigator software to evaluate neuronal loss and inflammation in hippocampal subfields. Establishing these effects after mTBI would provide a model for investigating regenerative approaches to replacing neurons through reprogramming in the hippocampal CA subfields.